Publications

2024 Publications

Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team. Neutralizing Antibody Immune Correlates for a Recombinant Protein Vaccine in the COVAIL Trial. Clinical Infectious Diseases. 26 SEP 2024.

Zinsou, J. F., Diemert, D. J., Dejon-Agobé, J. C., Adégbité, B. R., Honkpehedji, Y. J., Vodonou, K. G., ... & Adegnika, A. A. (2024). Safety and immunogenicity of the co-administered Na-APR-1 and Na-GST-1 hookworm vaccines in school-aged children in Gabon: a randomised, controlled, observer-blind, phase 1, dose-escalation trial. The Lancet Infectious Diseases.

deCamp, A. C., Corcoran, M. M., Fulp, W. J., Willis, J. R., Cottrell, C. A., Bader, D. L., ... & Schief, W. R. (2024). Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming. npj Vaccines, 9(1), 58.

2023 Publications

LS Scholte, DJ Leggat, KW Cohen, et. al. Ultrasound-guided lymph node fine-needle aspiration for evaluating post-vaccination germinal center responses in humans. STAR Protocols,
Volume 4, Issue 4, 2023, 102576, ISSN 2666-1667, https://doi.org/10.1016/j.xpro.2023.102576.

Nadine G. Rouphael, Angela R. Branche, David J. Diemert, et al. Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial. Journal of Infectious Diseases. 10 Aug 2023. https://doi.org/10.1093/infdis/jiad323

Guy de Bruyn, Joyce Wang, Annie Purvis, et al. Safety and immunogenicity of a variant-adapted SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant as a booster in adults primed with authorized vaccines ScienceDirect. 2023 Aug. https://doi.org/10.1016/j.eclinm.2023.102109

Kristen W. Cohen, Stephen C. De Rosa, William J. Fulp, et al. A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses Science Translational Medicine. 2023 May 24. PMID: 37224227. https://doi.org/10.1126/scitranslmed.adf3309

Angela R Branche, Nadine Rouphael, Cecilia Losada, et al. Immunogenicity of the BA.1 and BA.4/BA.5 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Bivalent Boosts: Preliminary Results From the COVAIL Randomized Clinical Trial Oxford. 2023 Apr 10. https://doi.org/10.1093/cid/ciad209

Allan C. deCamp, Martin M. Corcoran, Wiliam J. Fulp, et al. Human immunoglobulin gene allelic variation impacts germlinetargeting vaccine primingMedrxiv. 2023 March 10. https://doi.org/10.1101/2023.03.10.23287126 

2022 Publications

David J. Leggat, Kristen W. Cohen, Jordan R. Williams, et al. Vaccination induces HIV broadly neutralizing antibody precursors in humans Science. 2022 Dec 02. PMID: 36454825.

Diemert DJ, Zumer M, Campbell D, et al. Safety and immunogenicity of the Na-APR-1 hookworm vaccine in infection-naïve adults. Vaccine. 2022 Oct 06. PMID: 36114129.

Betouke Ongwe ME, Mouwenda YD, Stam KA, Kremsner PG, Lell B, Diemert D, et al. Investigation of urinary metabolomics in a phase I hookworm vaccine trial. PLoS ONE. 2022 Sep 26. PMID: 36155987.

Tornberg HN, Moezinia C, Wei C, Bernstein SA, Wei C, Al-Beyati R, Quan T, Diemert DJ Retraction: “Assessing the Dissemination of COVID-19 Articles Across Social Media With Altmetric and PlumX Metrics: Correlational Study”. J Med Internet Res. 2022 Jul 29. PMID: 35947853.

Branche AR, Rouphael NG, Diemert DJ, et al. SARS-CoV-2 Variant Vaccine Boosters Trial: Preliminary Analyses. medRxiv. 2022 Jul 15. PMID: 35898343.

Sridhar S, Joaquin A, Bonaparte MI, et al. Safety and immunogenicity of an AS03-adjuvanted SARS-CoV-2 recombinant protein vaccine (CoV2 preS dTM) in healthy adults: interim findings from a phase 2, randomised, dose-finding, multicentre study. Lancet Infectious Diseases. 2022 Jan 25; 22(5):636-648. PMID: 3509638.

2021 Publications

Potency testing for a recombinant protein vaccine early in clinical development: Lessons from the Schistosoma mansoni Tetraspanin 2 vaccine. Vaccine: X. Volume 8. 2021 June 6. PMID: 34169270

Controlled Infection of Humans with the Hookworm Parasite Necator americanus to Accelerate Vaccine Development: The Human Hookworm Vaccination/Challenge Model (HVCM). Current Topics in Microbiology and Immunology. 2021 July 31. PMID: 34328562

Characterization of T cell responses to co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in healthy adults in Gabon. PLOS Neglected Tropical Diseases. 2021 October 1. PMID: 34597297

Parasitic Helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host. PLOS Neglected Tropical Diseases. 2021 October 18. PMID: 34662329

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. The New England Journal of Medicine. 2021 Feb 4. PMID: 33378609

2020 Publications

Efficacy and Safety of the mRNA-1273-CoV-2 Vaccine. The New England Journal of Medicine. 2020 Dec 30. DOI: 10.1056/NEJMoa2035389

Safety and immunogenicity of co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in Gabonese adults: a randomised, controlled, double-blind, phase 1 dose-escalation trial. Lancet Infectious Diseases. 2020 Sep 11. PubMed PMID: 32926834

2019 Publications

Keitel WA, Potter GE, Diemert D, Bethony J, El Sahly HM, Kennedy JK, Patel SM, Plieskatt JL, Jones W, Deye G, Bottazzi ME, Hotez PJ, Atmar RL. A phase 1 study of the safety, reactogenicity, and immunogenicity of a Schistosoma mansoni vaccine with or without glucopyranosyl lipid A aqueous formulation (GLA-AF) in healthy adults from a non-endemic area. Vaccine. 2019 Sep 9. PubMed PMID: 31515141.

Hotez PJ, Bottazzi ME, Bethony JM, Diemert D. Advances in the Development of a Human Schistosomiasis Vaccine. Trends Parasitol. 2019 Feb;35(2):104-108. PubMed PMID: 30455112

Grande BM, Gerhard DS, Jiang A, Griner NB, Abramson JS, Alexander TB, Allen H, Ayers LW, Bethony JM, Bhatia K, Bowen J, Casper C, Choi JK, Culibrk L, Davidsen TM, Dyer MA, Gastier-Foster JM, Gesuwan P, Greiner TC, Gross TG, Hanf B, Harris NL, He Y, Irvin JD, Jaffe ES, Jones SJM, Kerchan P, Knoetze N, Leal FE, Lichtenberg TM, Ma Y, Martin JP, Martin MR, Mbulaiteye SM, Mullighan CG, Mungall AJ, Namirembe C, Novik K, Noy A, Ogwang MD, Omoding A, Orem J, Reynolds SJ, Rushton CK, Sandlund JT, Schmitz R, Taylor C, Wilson WH, Wright GW, Zhao EY, Marra MA, Morin RD, Staudt LM. Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma. Blood. 2019 Mar 21;133(12):1313-1324. doi: 10.1182/blood-2018-09-871418. Epub 2019 Jan 7. PubMed PMID: 30617194; PubMed Central PMCID: PMC6428665.

Ruantip S, Eamudomkarn C, Techasen A, Wangboon C, Sithithaworn J, Bethony JM, Itoh M, Sithithaworn P. Accuracy of Urine and Serum Assays for the Diagnosis of Strongyloidiasis by Three Enzyme-Linked Immunosorbent Assay Protocols. Am J Trop Med Hyg. 2019 Jan;100(1):127-129. doi: 10.4269/ajtmh.18-0569. PubMed PMID: 30398144; PubMed Central PMCID: PMC6335925.

Lynch RM, Mantus G, Encinales L, Pacheco N, Li G, Porras A, Mendoza AR, Peng J, Rengifo-Pardo M, Cruz MM, Harris E, Bethony JM, Simon GL, Chang AY. Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barré Syndrome. J Infect Dis. 2019 Jan 1;219(1):26-30. doi: 10.1093/infdis/jiy466. PubMed PMID: 30113672; PubMed Central PMCID: PMC6284544.
2018 Publications

Diemert D, Campbell D, Brelsford J, Leasure C, Li G, Peng J, Zumer M, Younes N, Bottazzi ME, Mejia R, Pritchard DI, Hawdon JM, Bethony JM. Controlled Human Hookworm Infection: Accelerating Human Hookworm Vaccine Development. Open Forum Infect Dis. 2018 Apr 19;5(5):ofy083. doi: 10.1093/ofid/ofy083. eCollection 2018 May. PubMed PMID: 29780848.

Diemert DJ, Bottazzi ME, Plieskatt J, Hotez PJ, Bethony JM. Lessons along the Critical Path: Developing Vaccines against Human Helminths. Trends Parasitol. 2018 Jul 28. pii: S1471-4922(18)30143-0. doi: 10.1016/j.pt.2018.07.005. Review. PubMed PMID: 30064902.

Baay MFD, Richie TL, Neels P; Session chairs at the second Human Challenge Trials meeting (Cavaleri M, Chilengi R, Diemert D, Hoffman SL, Johnson R, Kirkpatrick BD, Knezevic I, Laurens M, McShane H, Njuguna P, Older Aguilar A, Pollard AJ, Riddle M, Sauerwein R, Southern J, Tribble D, Wildfire). Human challenge trials in vaccine development, Rockville, MD, USA, September 28-30, 2017. Biologicals, 2018 Mar. PubMed PMID: 29573967.

Khoontawad J, Intuyod K, Rucksaken R, Hongsrichan N, Pairojkul C, Pinlaor P, Boonmars T, Wongkham C, Jones A, Plieskatt J, Potriquet J, Bethony JM, Mulvenna J, Pinlaor S. Discovering proteins for chemoprevention and chemotherapy by curcumin in liver fluke infection-induced bile duct cancer. PLoS One. 2018 Nov 15;13(11):e0207405. doi: 10.1371/journal.pone.0207405. eCollection 2018. PubMed PMID: 30440021; PubMed Central PMCID: PMC6237386.

Ho CY, Castillo N, Encinales L, Porras A, Mendoza AR, Lynch R, Nemirovsky A,
Mantus G, DeBiasi RL, Bethony JM, Simon GL, Chang AY. Second-trimester Ultrasoundand Neuropathologic Findings in Congenital Zika Virus Infection. Pediatr Infect Dis J. 2018 Dec;37(12):1290-1293. doi:  10.1097/INF.0000000000002080. PubMed PMID: 30408008; PubMed Central PMCID: PMC6233735.

Chang AY, Tritsch S, Reid SP, Martins K, Encinales L, Pacheco N, Amdur RL, Porras-Ramirez A, Rico-Mendoza A, Li G, Peng J, Firestein GS, Simon GL, Bethony JM. The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection. Diseases. 2018 Oct 20;6(4). pii: E95. doi: 10.3390/diseases6040095. PubMed PMID: 30347791; PubMed Central PMCID: PMC6313749.

Wangboon C, Worasith C, Thanan R, Eamudomkarn C, Techasen A, Sithithaworn J, Loilome W, Chamadol N, Pinlaor S, Jumnainsong A, Yongvanit P, Khuntikeo N, Bethony JM, Sithithaworn P. Evaluation of a short term effect of praziquantel treatment in opisthorchiasis-induced hepatobiliary inflammation by urinary. 8-oxodG. Acta Trop. 2019 Jan;189:124-128. doi: 10.1016/j.actatropica.2018.10.003. Epub 2018 Oct 12. PubMed PMID: 30321522.

Chang AY, Lynch R, Martins K, Encinales L, Cadena Bonfanti AÁ, Pacheco N, Reid SP, Lara Sarabia OE, González Torres HJ, Mejia Castillo S, Barrios Taborda O, Alarcon Gomez M, Guerra Duran B, Martinez Giraldo V, Benitez Ospino A, Porras A, Mendoza AR, Mantus G, Li G, Peng J, Kamalapathy P, Avendaño Echavez LG, Dowd KA, Rengifo-Pardo M, Barraza PP, Jiménez Hernàndez D, González Coba A, De La Hoz Mendoza K, Bethony JM, Simon GL. Long-term clinical outcomes of Zika-associated Guillain-Barré syndrome. Emerg Microbes Infect. 2018 Aug 22;7(1):148. doi: 10.1038/s41426-018-0151-9. PubMed PMID: 30131486; PubMed Central PMCID: PMC6104068.

Chang AY, Bethony JM, Simon GL, Encinales L, Firestein GS. Reply. Arthritis Rheumatol. 2018 Nov;70(11):1891-1892. doi: 10.1002/art.40663. Epub 2018 Aug 27. PubMed PMID: 30003712; PubMed Central PMCID: PMC6203595.

Chang AY, Bethony JM, Simon GL, Reid SP, Encinales L, Firestein GS. Reply. Arthritis Rheumatol. 2018 Nov;70(11):1893. doi: 10.1002/art.40664. Epub 2018 Aug 27. PubMed PMID: 30003684; PubMed Central PMCID: PMC6203644.

Wangboon C, Yongvanit P, Loilome W, Thanan R, Worasith C, Eamudomkarn C, Chamadol N, Mairiang E, Sithithaworn J, Saichua P, Sripa B, Khuntikeo N, Bethony JM, Sithithaworn P. Elevated Levels of Urinary 8-oxodG Correlate with Persistent Periductal Fibrosis after Praziquantel Treatment in Chronic Opisthorchiasis. Am J Trop Med Hyg. 2018 Jun;98(6):1763-1769. doi: 10.4269/ajtmh.17-0971. Epub 2018 Apr 5. PubMed PMID: 29637887; PubMed Central PMCID: PMC6086152.

Chang AY, Bethony JM, Simon GL, Encinales L. Reply. Arthritis Rheumatol. 2018 Jul;70(7):1166-1167. doi: 10.1002/art.40474. Epub 2018 May 7. PubMed PMID: 29513923; PubMed Central PMCID: PMC6019604.

Chang AY, Martins KAO, Encinales L, Reid SP, Acuña M, Encinales C, Matranga CB, Pacheco N, Cure C, Shukla B, Ruiz Arteta T, Amdur R, Cazares LH, Gregory M, Ward MD, Porras A, Rico Mendoza A, Dong L, Kenny T, Brueggemann E, Downey LG,
Kamalapathy P, Lichtenberger P, Falls O, Simon GL, Bethony JM, Firestein GS. Chikungunya Arthritis Mechanisms in the Americas: A Cross-Sectional Analysis of Chikungunya Arthritis Patients Twenty-Two Months After Infection Demonstrating No Detectable Viral Persistence in Synovial Fluid. Arthritis Rheumatol. 2018 Apr;70(4):585-593. doi: 10.1002/art.40383. Epub 2018 Mar 7. PubMed PMID: 29266856.

Chang AY, Encinales L, Porras A, Pacheco N, Reid SP, Martins KAO, Pacheco S,  Bravo E, Navarno M, Rico Mendoza A, Amdur R, Kamalapathy P, Firestein GS, Bethony JM, Simon GL. Frequency of Chronic Joint Pain Following Chikungunya Virus Infection: A Colombian Cohort Study. Arthritis Rheumatol. 2018 Apr;70(4):578-584. doi: 10.1002/art.40384. Epub 2018 Mar 2. PubMed PMID: 29266783.

Khoontawad J, Intuyod K, Rucksaken R, Hongsrichan N, Pairojkul C, Pinlaor P, Boonmars T, Wongkham C, Jones A, Plieskatt J, Potriquet J, Bethony JM, Mulvenna J, Pinlaor S. Discovering proteins for chemoprevention and chemotherapy by curcumin in liver fluke infection-induced bile duct cancer. PLoS One. 2018 Nov 15;13(11):e0207405. doi: 10.1371/journal.pone.0207405. eCollection 2018. PubMed PMID: 30440021; PubMed Central PMCID: PMC6237386.
2017 Publications
Diemert D, Freire J, Valente V, Fraga G, Talles F, Grahek S, Campbell D, Periago MV, Enk M, Gazzinelli MF, Bottazzi ME, Hamilton R, Brelsford J, Yakovleva A, Li G, Peng J, Correa-Oliveira O, Hotez P, Bethony J. Safety and Immunogenicity of the Na-GST-1 Hookworm Vaccine in Brazilian and American Adults. PLOS Negl Trop Dis.  2017 May 2;11(5):e0005574.
Brelsford JB, Plieskatt JL, Yakovleva A, Li G, Keegan BP, Jariwala A, Peng J, Xia P, Campbell D, Periago MV, Correa-Oliveira R, Bottazzi ME, Hotez PJ, Bethony JM†, Diemert D†. Advances in Neglected Tropical Disease Vaccines: Developing Relative Potency and Functional Assays for the Na-GST-1/Alhydrogel Hookworm Vaccine. PLoS Negl Trop Dis. 2017 Feb  13;11(2):e0005385. †Co-Senior Authors.
Diemert DJ, Lobato L, Styczynski A, Zumer M, Soares A, Gazzinelli MF. A Comparison of the Quality of Informed Consent for Clinical Trials of an Experimental Hookworm Vaccine Conducted in Developed and Developing Countries. PLoS Negl Trop Dis. 2017 Jan 23;11(1):e0005327. 
Gazzinelli A, Oliveira-Prado R, Matoso LF, Veloso BM, Andrade G, Kloos H, Bethony JM, Assunção RM, Correa-Oliveira R. Schistosoma mansoni reinfection: Analysis of risk factors by classification and regression tree (CART) modeling. PLoS One. 2017 Aug 16;12(8):e0182197. doi: 10.1371/journal.pone.0182197. eCollection 2017. PubMed PMID: 28813451; PubMed Central PMCID: PMC5558968.
Potriquet J, Laohaviroj M, Bethony JM, Mulvenna J. A modified FASP protocol for high-throughput preparation of protein samples for mass spectrometry. PLoS One. 2017 Jul 27;12(7):e0175967. doi: 10.1371/journal.pone.0175967. eCollection 2017. PubMed PMID: 28750034; PubMed Central PMCID: PMC5531558.
Yakovleva A, Plieskatt JL, Jensen S, Humeida R, Lang J, Li G, Bracci P, Silver S, Bethony JM. Fit for genomic and proteomic purposes: Sampling the fitness of nucleic acid and protein derivatives from formalin fixed paraffin embedded tissue. PLoS One. 2017 Jul 25;12(7):e0181756. doi: 10.1371/journal.pone.0181756. eCollection 2017. PubMed PMID: 28742856; PubMed Central PMCID: PMC5526578.
George S, Geldhof P, Albonico M, Ame SM, Bethony JM, Engels D, Mekonnen Z, Montresor A, Hem S, Tchuem-Tchuenté LA, Huong NT, Kang G, Vercruysse J, Levecke B. The molecular speciation of soil-transmitted helminth eggs collected from school children across six endemic countries. Trans R Soc Trop Med Hyg. 2017 Jan 18. doi: 10.1093/trstmh/trw078. [Epub ahead of print] PubMed PMID: 28100811; PubMed Central PMCID: PMC5584671.
 Yakovleva A, Plieskatt JL, Jensen S, Humeida R, Lang J, Li G, Bracci P, Silver S, Bethony JM. Fit for genomic and proteomic purposes: Sampling the fitness of nucleic acid and protein derivatives from formalin fixed paraffin embedded tissue. PLoS One. 2017 Jul 25;12(7):e0181756. doi: 10.1371/journal.pone.0181756. eCollection 2017. PubMed PMID: 28742856; PubMed Central PMCID: PMC5526578.
Khoontawad J, Pairojkul C, Rucksaken R, Pinlaor P, Wongkham C, Yongvanit P, Pugkhem A, Jones A, Plieskatt J, Potriquet J, Bethony J, Pinlaor S, Mulvenna J. Differential Protein Expression Marks the Transition From Infection With Opisthorchis viverrini to Cholangiocarcinoma. Mol Cell Proteomics. 2017 May;16(5):911-923. doi: 10.1074/mcp.M116.064576. Epub 2017 Feb 23. PubMed PMID: 28232516; PubMed Central PMCID: PMC5417829.
2016 Publications
Loukas A, Hotez PJ, Diemert D, Yazdanbakhsh M, McCarthy JS, Correa-Oliveira R, Croese J, Bethony JM. Hookworm Infection. Nat Rev Dis Primers. 2016 Dec 8;2:16088. 
Bartsch SM, Hotez PJ, Asti L, Zapf KM, Bottazzi ME, Diemert DJ, Lee BY. The Global Economic and Health Burden of Human Hookworm Infection. PLoS Negl Trop Dis. 2016 Sep 8;10(9):e0004922. 
Gazzinelli MF, Lobato L, Andrade G, Matoso LF, Diemert DJ, Gazzinelli A. Improving the understanding of schistosomiasis among adolescents in endemic areas in Brazil: A comparison of educational methods. Patient Educ Couns. 2016 Oct;99(10):1657-62. Epub 2016 Apr 26. PubMed PMID: 27180618.  
Bartsch SM, Hotez PJ, Hertenstein DL, Diemert DJ, Zapf KM, Bottazzi ME, Bethony JM, Brown ST, Lee BY. Modeling the economic and epidemiologic impact of hookworm vaccine and mass drug administration (MDA) in Brazil, a high transmission setting. Vaccine. 2016 Apr 27;34(19):2197-206.
de Assis RR, Ludolf F, Nakajima R, Jasinskas A, Oliveira GC, Felgner PL, Gaze ST, Loukas A, LoVerde PT, Bethony JM, Correa-Oliveira R, Calzavara-Silva CE. A next-generation proteome array for Schistosoma mansoni. Int J Parasitol. 2016 Jun;46(7):411-5. doi: 10.1016/j.ijpara.2016.04.001. Epub 2016 Apr 27. PubMed PMID: 27131510.
Papatpremsiri A, Junpue P, Loukas A, Brindley PJ, Bethony JM, Sripa B, Laha T. Immunization and challenge shown by hamsters infected with Opisthorchis viverrini following exposure to gamma-irradiated metacercariae of this carcinogenic liver fluke. J Helminthol. 2016 Jan;90(1):39-47. doi: 10.1017/S0022149X14000741. Epub 2014 Oct 15. PubMed PMID: 25315797; PubMed Central PMCID: PMC4943860.
2015 Publications
Periago MV, Diniz RC, Pinto SA, Yakovleva A, Correa-Oliveira R, Diemert DJ, Bethony JM. The Right Tool for the Job: Detection of Soil-Transmitted Helminths in Areas Co-endemic for Other Helminths. PLoS Negl Trop Dis. 2015 Aug 4;9(8):e0003967.
Blair P, Diemert D. Update on prevention and treatment of intestinal helminth infections. Curr Infect Dis Rep. 2015 Mar;17(3):465.
Worasith C, Kamamia C, Yakovleva A, Duenngai K, Wangboon C, Sithithaworn J, Watwiengkam N, Namwat N, Techasen A, Loilome W, Yongvanit P, Loukas A, Sithithaworn P, Bethony JM. Advances in the Diagnosis of Human Opisthorchiasis: Development of Opisthorchis viverrini Antigen Detection in Urine. PLoS Negl Trop  Dis. 2015 Oct 20;9(10):e0004157. doi: 10.1371/journal.pntd.0004157. eCollection 2015. PubMed PMID: 26485024; PubMed Central PMCID: PMC4618926.
Saichua P, Yakovleva A, Kamamia C, Jariwala AR, Sithithaworn J, Sripa B, Brindley PJ, Laha T, Mairiang E, Pairojkul C, Khuntikeo N, Mulvenna J, Sithithaworn P, Bethony JM. Levels of 8-OxodG. Predict Hepatobiliary Pathology in  Opisthorchis viverrini Endemic Settings in Thailand. PLoS Negl Trop Dis. 2015 Jul 31;9(7):e0003949. doi: 10.1371/journal.pntd.0003949. eCollection 2015. PubMed PMID: 26230769; PubMed Central PMCID: PMC4521778.
Pearson MS, Jariwala AR, Abbenante G, Plieskatt J, Wilson D, Bottazzi ME, Hotez PJ, Keegan B, Bethony JM, Loukas A. New tools for NTD vaccines: A case study of quality control assays for product development of the human hookworm vaccine. Na-APR-1M74. Hum Vaccine Immunother. 2015;11(5):1251-7. doi: 10.4161/21645515.2014.980199. PubMed PMID: 26018444; PubMed Central PMCID: PMC4514234.
Pearson MS, Becker L, Driguez P, Young ND, Gaze S, Mendes T, Li XH, Doolan DL, Midzi N, Mduluza T, McManus DP, Wilson RA, Bethony JM, Nausch N, Mutapi F, Felgner PL, Loukas A. Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates. Front Immunol. 2015 May 5;6:213. doi:10.3389/fimmu.2015.00213. eCollection 2015. PubMed PMID: 25999951; PubMed Central PMCID: PMC4419842.
Chaiyadet S, Sotillo J, Smout M, Cantacessi C, Jones MK, Johnson MS, Turnbull L, Whitchurch CB, Potriquet J, Laohaviroj M, Mulvenna J, Brindley PJ, Bethony JM, Laha T, Sripa B, Loukas A. Carcinogenic Liver Fluke Secretes Extracellular Vesicles That Promote Cholangiocytes to Adopt a Tumorigenic Phenotype. J Infect Dis. 2015 Nov 15;212(10):1636-45. doi: 10.1093/infdis/jiv291. Epub 2015 May 17. PubMed PMID: 25985904; PubMed Central PMCID: PMC4621255.
Pearson MS, Jariwala AR, Abbenante G, Plieskatt J, Wilson D, Bottazzi ME, Hotez PJ, Keegan B, Bethony JM, Loukas A. New tools for NTD vaccines: A case study of quality control assays for product development of the human hookworm vaccine Na-APR-1M74. Hum Vaccin Immunother. 2015;11(5):1251-7. doi: 10.4161/21645515.2014.980199. PubMed PMID: 26018444; PubMed Central PMCID: PMC4514234.
Plieskatt J, Rinaldi G, Feng Y, Peng J, Easley S, Jia X, Potriquet J, Pairojkul C, Bhudhisawasdi V, Sripa B, Brindley PJ, Bethony J, Mulvenna J. A microRNA profile associated with Opisthorchis viverrini-induced cholangiocarcinoma in tissue and plasma. BMC Cancer. 2015 Apr 23;15:309. doi: 10.1186/s12885-015-1270-5. PubMed PMID: 25903557; PubMed Central PMCID: PMC4417245.
2014 Publications
Lobato L, Bethony JM, Pereira FB, Grahek SL, Diemert D, Gazzinelli MF. Impact of gender on the decision to participate in a clinical trial: a cross-sectional study. BMC Public Health. 2014 Nov 6;14:1156.  
Peng J, Feng Y, Rinaldi G, Levine P, Easley S, Martinez E, Hashmi S, Sadeghi N, Brindley PJ, Mulvenna JP, Bethony JM, Plieskatt JL. Profiling miRNAs in nasopharyngeal carcinoma FFPE tissue by microarray and Next Generation Sequencing. Genom Data. 2014 Aug 27;2:285-9. doi: 10.1016/j.gdata.2014.08.005. eCollection 2014 Dec. PubMed PMID: 26484110; PubMed Central PMCID: PMC4535902.  
Peng J, Feng Y, Rinaldi G, Yonglitthipagon P, Easley SE, Laha T, Pairojkul C, Bhudhisawasdi V, Sripa B, Brindley PJ, Mulvenna JP, Bethony JM, Plieskatt JL. The miRNAome of Opisthorchis viverrini induced intrahepatic cholangiocarcinoma. Genom Data. 2014 Aug 28;2:274-9. doi: 10.1016/j.gdata.2014.08.007. eCollection 2014 Dec. PubMed PMID: 26484108; PubMed Central PMCID: PMC4535865.  
Gaze S, Bethony JM, Periago MV. Immunology of experimental and natural human hookworm infection. Parasite Immunol. 2014 Aug;36(8):358-66. Review. PubMed PMID: 25337625.  
Levecke B, Montresor A, Albonico M, Ame SM, Behnke JM, Bethony JM, Noumedem CD, Engels D, Guillard B, Kotze AC, Krolewiecki AJ, McCarthy JS, Mekonnen Z, Periago MV, Sopheak H, Tchuem-Tchuenté LA, Duong TT, Huong NT, Zeynudin A, Vercruysse J. Assessment of anthelmintic efficacy of mebendazole in school children in six countries where soil-transmitted helminths are endemic. PLoS Negl Trop Dis. 2014 Oct 9;8(10):e3204. doi: 10.1371/journal.pntd.0003204. eCollection 2014 Oct. PubMed PMID: 25299391; PubMed Central PMCID: PMC4191962.  
Plieskatt JL, Feng Y, Rinaldi G, Mulvenna JP, Bethony JM, Brindley PJ. Circumventing qPCR inhibition to amplify miRNAs in plasma. Biomark Res. 2014 Jul 22;2:13. doi: 10.1186/2050-7771-2-13. eCollection 2014. PubMed PMID: 25075309; PubMed Central PMCID: PMC4114091.  
Plieskatt JL, Rinaldi G, Feng Y, Peng J, Yonglitthipagon P, Easley S, Laha T, Pairojkul C, Bhudhisawasdi V, Sripa B, Brindley PJ, Mulvenna JP, Bethony JM. Distinct miRNA signatures associate with subtypes of cholangiocarcinoma from infection with the tumourigenic liver fluke Opisthorchis viverrini. J Hepatol. 2014 Oct;61(4):850-8. doi: 10.1016/j.jhep.2014.05.035. Epub 2014 Jun 3. PubMed PMID: 25017828.  
Pinot de Moira A, Fitzsimmons CM, Jones FM, Wilson S, Cahen P, Tukahebwa E, Mpairwe H, Mwatha JK, Bethony JM, Skov PS, Kabatereine NB, Dunne DW. Suppression of basophil histamine release and other IgE-dependent responses in childhood Schistosoma mansoni/hookworm coinfection. J Infect Dis. 2014 Oct 15;210(8):1198-206. doi: 10.1093/infdis/jiu234. Epub 2014 Apr 29. PubMed PMID: 24782451; PubMed Central PMCID: PMC4176447.  
Gaze S, Driguez P, Pearson MS, Mendes T, Doolan DL, Trieu A, McManus DP, Gobert GN, Periago MV, Correa Oliveira R, Cardoso FC, Oliveira G, Nakajima R, Jasinskas A, Hung C, Liang L, Pablo J, Bethony JM, Felgner PL, Loukas A. An immunomics approach to schistosome antigen discovery: antibody signatures of naturally resistant and chronically infected individuals from endemic areas. PLoS Pathog. 2014 Mar 27;10(3):e1004033. doi: 10.1371/journal.ppat.1004033. eCollection 2014 Mar. PubMed PMID: 24675823; PubMed Central PMCID: PMC3968167.  
Aka P, Emmanuel B, Vila MC, Jariwala A, Nkrumah F, Periago MV, Neequaye J, Kiruthu C, Levine PH, Biggar RJ, Bhatia K, Bethony JM, Mbulaiteye SM. Elevated serum levels of interleukin-6 in endemic Burkitt lymphoma in Ghana. Hematol Oncol. 2014 Dec;32(4):218-20. doi: 10.1002/hon.2121. Epub 2014 Jan 6. PubMed PMID: 24493366; PubMed Central PMCID: PMC4293153.  
Plieskatt JL, Rinaldi G, Feng Y, Levine PH, Easley S, Martinez E, Hashmi S, Sadeghi N, Brindley PJ, Bethony JM, Mulvenna JP. Methods and matrices: approaches to identifying miRNAs for nasopharyngeal carcinoma. J Transl Med. 2014 Jan 6;12:3. doi: 10.1186/1479-5876-12-3. PubMed PMID: 24393330; PubMed Central PMCID: PMC3895762.  
Peng J, Feng Y, Rinaldi G, Levine P, Easley S, Martinez E, Hashmi S, Sadeghi N, Brindley PJ, Mulvenna JP, Bethony JM, Plieskatt JL. Profiling miRNAs in nasopharyngeal carcinoma FFPE tissue by microarray and Next Generation Sequencing. Genom Data. 2014 Aug 27;2:285-9. doi: 10.1016/j.gdata.2014.08.005.eCollection 2014 Dec. PubMed PMID: 26484110; PubMed Central PMCID: PMC4535902.  
Peng J, Feng Y, Rinaldi G, Yonglitthipagon P, Easley SE, Laha T, Pairojkul C, Bhudhisawasdi V, Sripa B, Brindley PJ, Mulvenna JP, Bethony JM, Plieskatt JL. The miRNAome of Opisthorchis viverrini induced intrahepatic cholangiocarcinoma. GenomData. 2014 Aug 28;2:274-9. doi: 10.1016/j.gdata.2014.08.007. eCollection 2014 Dec. PubMed PMID: 26484108; PubMed Central PMCID: PMC4535865.  
Plieskatt JL, Feng Y, Rinaldi G, Mulvenna JP, Bethony JM, Brindley PJ. Circumventing qPCR inhibition to amplify miRNAs in plasma. Biomark Res. 2014 Jul 22;2:13. doi: 10.1186/2050-7771-2-13. eCollection 2014. PubMed PMID: 25075309; PubMed Central PMCID: PMC4114091  
Plieskatt JL, Rinaldi G, Feng Y, Peng J, Yonglitthipagon P, Easley S, Laha T, Pairojkul C, Bhudhisawasdi V, Sripa B, Brindley PJ, Mulvenna JP, Bethony JM. Distinct miRNA signatures associate with subtypes of cholangiocarcinoma from infection with the tumourigenic liver fluke Opisthorchis viverrini. J Hepatol. 2014 Oct;61(4):850-8. doi: 10.1016/j.jhep.2014.05.035. Epub 2014 Jun 3. PubMed
PMID: 25017828.		  
Plieskatt J, Rinaldi G, Brindley PJ, Jia X, Potriquet J, Bethony J, Mulvenna J. Bioclojure: a functional library for the manipulation of biological sequences. Bioinformatics. 2014 Sep 1;30(17):2537-9. doi: 10.1093/bioinformatics/btu311. Epub 2014 May 2. PubMed PMID: 24794932; PubMed Central PMCID: PMC4147884.  
Plieskatt JL, Rinaldi G, Feng Y, Levine PH, Easley S, Martinez E, Hashmi S, Sadeghi N, Brindley PJ, Bethony JM, Mulvenna JP. Methods and matrices: approaches to identifying miRNAs for nasopharyngeal carcinoma. J Transl Med. 2014 Jan 6;12:3. doi: 10.1186/1479-5876-12-3. PubMed PMID: 24393330; PubMed Central PMCID: PMC3895762.
2013 Publications
Geiger SM, Jardim-Botelho A, Williams W, Alexander N, Diemert DJ, Bethony JM. 
Serum CCL11 (eotaxin-1) and CCL17 (TARC) are serological indicators of multiple helminth infections and are driven by Schistosoma mansoni infection in humans. Trop Med Int Health. 2013 Jun;18(6):750-60.
Saichua P, Sithithaworn P, Jariwala AR, Diemert DJ, Sithithaworn J, Sripa B, Laha T, Mairiang E, Pairojkul C, Periago MV, Khuntikeo N, Mulvenna J, Bethony JM. 
Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis. 
PLoS Negl Trop Dis. 2013 May 23;7(5):e2228. 
Hotez PJ, Diemert D, Bacon KM, Beaumier C, Bethony JM, Bottazzi ME, Brooker S, Couto AR, Freire Mda S, Homma A, Lee BY, Loukas A, Loblack M, Morel CM, Oliveira RC, Russell PK. The Human Hookworm Vaccine. Vaccine. 2013 Apr 18;31 Suppl2:B227-32. Review.
Plieskatt JL, Deenonpoe R, Mulvenna JP, Krause L, Sripa B, Bethony JM, Brindley PJ. Infection with the carcinogenic liver fluke Opisthorchis viverrini modifies intestinal and biliary microbiome. FASEB J. 2013 Nov;27(11):4572-84. doi: 10.1096/fj.13-232751. Epub 2013 Aug 7. PubMed PMID: 23925654; PubMed Central
PMCID: PMC3804743.
Aka P, Vila MC, Jariwala A, Nkrumah F, Emmanuel B, Yagi M, Palacpac NM, Periago MV, Neequaye J, Kiruthu C, Tougan T, Levine PH, Biggar RJ, Pfeiffer RM, Bhatia K, Horii T, Bethony JM, Mbulaiteye SM. Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparum malaria stage-specific antigen antibody response. Blood. 2013 Aug 1;122(5):629-35. doi: 10.1182/blood-2012-12-475665. Epub 2013 May 3. PubMed PMID: 23645841; PubMed
Central PMCID: PMC3731925.
Plieskatt JL, Deenonpoe R, Mulvenna JP, Krause L, Sripa B, Bethony JM, Brindley PJ. Infection with the carcinogenic liver fluke Opisthorchis viverrini modifies intestinal and biliary microbiome. FASEB J. 2013 Nov;27(11):4572-84. doi: 10.1096/fj.13-232751. Epub 2013 Aug 7. PubMed PMID: 23925654; PubMed Central
PMCID: PMC3804743.
2012 Publications
Zhan B, Santiago H, Keegan B, Gillespie P, Xue J, Bethony J, de Oliveira LM, Jiang D, Diemert D, Xiao SH, Jones K, Feng X, Hotez PJ, Bottazzi ME. Fusion of Na-ASP-2 with human immunoglobulin Fcγ abrogates histamine release from basophils sensitized with anti-Na-ASP-2 IgE. Parasite Immunol. 2012 Aug-Sep;34(8-9):404-11.
Pearson MS, Tribolet L, Cantacessi C, Periago MV, Valero MA, Jariwala AR, Hotez P, Diemert D, Loukas A, Bethony J. Molecular mechanisms of hookworm disease: stealth, virulence, and vaccines. J Allergy Clin Immunol. 2012 Jul;130(1):13-21. Review.
Diemert DJ, Pinto AG, Freire J, Jariwala A, Santiago H, Hamilton RG, Periago MV, Loukas A, Tribolet L, Mulvenna J, Correa-Oliveira R, Hotez PJ, Bethony JM. Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: implications for the development of vaccines against helminths. J Allergy Clin Immunol. 2012 Jul;130(1):169-76.e6.
Pinot de Moira A, Jones FM, Wilson S, Tukahebwa E, Fitzsimmons CM, Mwatha JK, Bethony JM, Kabatereine NB, Dunne DW. Effects of treatment on IgE responsesagainst parasite allergen-like proteins and immunity to reinfection in childhood schistosome and hookworm coinfections. Infect Immun. 2013 Jan;81(1):23-32. doi:10.1128/IAI.00748-12. Epub 2012 Oct 15. PubMed PMID: 23071136; PubMed Central PMCID: PMC3536155.
Periago MV, Bethony JM. Hookworm virulence factors: making the most of the host. Microbes Infect. 2012 Dec;14(15):1451-64. doi: 10.1016/j.micinf.2012.09.002. Epub 2012 Sep 21. Review. PubMed PMID: 23006854.
Sripa B, Brindley PJ, Mulvenna J, Laha T, Smout MJ, Mairiang E, Bethony JM, Loukas A. The tumorigenic liver fluke Opisthorchis viverrini--multiple pathways to cancer. Trends Parasitol. 2012 Oct;28(10):395-407. doi: 10.1016/j.pt.2012.07.006. Epub 2012 Sep 1. Review. PubMed PMID: 22947297; PubMed Central PMCID: PMC3682777.
Lobato L, Miranda A, Faria IM, Bethony JM, Gazzinelli MF. Development of cognitive abilities of children infected with helminths through health education. Rev Soc Bras Med Trop. 2012 Jul-Aug;45(4):514-9. PubMed PMID: 22930049.
Sripa B, Thinkhamrop B, Mairiang E, Laha T, Kaewkes S, Sithithaworn P, Periago MV, Bhudhisawasdi V, Yonglitthipagon P, Mulvenna J, Brindley PJ, Loukas A, Bethony JM.
Elevated plasma IL-6 associates with increased risk of advanced fibrosis and cholangiocarcinoma in individuals infected by Opisthorchis viverrini. 
PLoS Negl Trop Dis. 2012;6(5):e1654. doi: 10.1371/journal.pntd.0001654. Epub 2012 May 22. PubMed PMID: 22629477; PubMed Central PMCID: PMC3358341.
Pearson MS, Pickering DA, McSorley HJ, Bethony JM, Tribolet L, Dougall AM, Hotez PJ, Loukas A. Enhanced protective efficacy of a chimeric form of the schistosomiasis vaccine antigen Sm-TSP-2. PLoS Negl Trop Dis. 2012;6(3):e1564. doi: 10.1371/journal.pntd.0001564. Epub 2012 Mar 13. PubMed PMID: 22428079; PubMed Central PMCID: PMC3302818.
Gaze S, McSorley HJ, Daveson J, Jones D, Bethony JM, Oliveira LM, Speare R, McCarthy JS, Engwerda CR, Croese J, Loukas A. Characterising the mucosal and systemic immune responses to experimental human hookworm infection. PLoS Pathog.  2012 Feb;8(2):e1002520. doi: 10.1371/journal.ppat.1002520. Epub 2012 Feb 9. PubMed PMID: 22346753; PubMed Central PMCID: PMC3276555.
Mathias DK, Plieskatt JL, Armistead JS, Bethony JM, Abdul-Majid KB, McMillan  A, Angov E, Aryee MJ, Zhan B, Gillespie P, Keegan B, Jariwala AR, Rezende W, Bottazzi ME, Scorpio DG, Hotez PJ, Dinglasan RR. Expression, immunogenicity, histopathology, and potency of a mosquito-based malaria transmission-blocking recombinant vaccine. Infect Immun. 2012 Apr;80(4):1606-14. doi: 10.1128/IAI.06212-11. Epub 2012 Feb 6. PubMed PMID: 22311924; PubMed Central
PMCID: PMC3318422.
Mathias DK, Plieskatt JL, Armistead JS, Bethony JM, Abdul-Majid KB, McMillan A, Angov E, Aryee MJ, Zhan B, Gillespie P, Keegan B, Jariwala AR, Rezende W, Bottazzi ME, Scorpio DG, Hotez PJ, Dinglasan RR. Expression, immunogenicity, histopathology, and potency of a mosquito-based malaria transmission-blocking recombinant vaccine. Infect Immun. 2012 Apr;80(4):1606-14. doi:10.1128/IAI.06212-11. Epub 2012 Feb 6. PubMed PMID: 22311924; PubMed Central
PMCID: PMC3318422.
2011 Publications
Schneider B, Jariwala AR, Periago MV, Gazzinelli MF, Bose SN, Hotez PJ, Diemert DJ, Bethony JM. A history of hookworm vaccine development. Hum Vaccin. 2011 Nov;7(11):1234-44. Review.
Cundill B, Alexander N, Bethony JM, Diemert D, Pullan RL, Brooker S. Rates and intensity of re-infection with human helminths after treatment and the influence of individual, household, and environmental factors in a Brazilian community. Parasitology. 2011 Sep;138(11):1406-16.
Geiger SM, Alexander ND, Fujiwara RT, Brooker S, Cundill B, Diemert DJ, Correa-Oliveira R, Bethony JM. Necator americanus and helminth co-infections: further down-modulation of hookworm-specific type 1 immune responses. PLoS Negl Trop Dis. 2011 Sep;5(9):e1280.
Alexander N, Cundill B, Sabatelli L, Bethony JM, Diemert D, Hotez P, Smith PG, Rodrigues LC, Brooker S. Selection and quantification of infection endpoints for trials of vaccines against intestinal helminths. Vaccine. 2011 May 9;29(20):3686-94.
Mulvenna J, Yonglitthipagon P, Sripa B, Brindley PJ, Loukas A, Bethony JM. Banking on the future: biobanking for "omics" approaches to biomarker discovery for Opisthorchis-induced cholangiocarcinoma in Thailand. Parasitol Int. 2012 Mar;61(1):173-7. doi: 10.1016/j.parint.2011.06.005. Epub 2011 Aug 9. PubMed PMID: 21855650; PubMed Central PMCID: PMC3223551.
Geiger SM, Fujiwara RT, Freitas PA, Massara CL, Dos Santos Carvalho O, Corrêa-Oliveira R, Bethony JM. Excretory-secretory products from hookworm l(3) and adult worms suppress proinflammatory cytokines in infected individuals. J Parasitol Res. 2011;2011:512154. doi: 10.1155/2011/512154. Epub 2011 Jun 9. PubMed PMID: 21772981; PubMed Central PMCID: PMC3135091.
Mairiang E, Laha T, Bethony JM, Thinkhamrop B, Kaewkes S, Sithithaworn P, Tesana S, Loukas A, Brindley PJ, Sripa B. Ultrasonography assessment of hepatobiliary abnormalities in 3359 subjects with Opisthorchis viverrini infection in endemic areas of Thailand. Parasitol Int. 2012 Mar;61(1):208-11. doi: 10.1016/j.parint.2011.07.009. Epub 2011 Jul 14. PubMed PMID: 21771664; PubMed Central PMCID: PMC4096033.
Nair SS, Bommana A, Pakala SB, Ohshiro K, Lyon AJ, Suttiprapa S, Periago MV, Laha T, Hotez PJ, Bethony JM, Sripa B, Brindley PJ, Kumar R. Inflammatory response to liver fluke Opisthorchis viverrini in mice depends on host master coregulator MTA1, a marker for parasite-induced cholangiocarcinoma in humans. Hepatology. 2011 Oct;54(4):1388-97. doi: 10.1002/hep.24518. Epub 2011 Sep 6. PubMed PMID: 21725997; PubMed Central PMCID: PMC3184196.
Loukas A, Gaze S, Mulvenna JP, Gasser RB, Brindley PJ, Doolan DL, Bethony JM, Jones MK, Gobert GN, Driguez P, McManus DP, Hotez PJ. Vaccinomics for the major blood feeding helminths of humans. OMICS. 2011 Sep;15(9):567-77. doi: 10.1089/omi.2010.0150. Epub 2011 Jun 16. Review. PubMed PMID: 21679087.
Nair SS, Bommana A, Bethony JM, Lyon AJ, Ohshiro K, Pakala SB, Rinaldi G, Keegan B, Suttiprapa S, Periago MV, Hotez PJ, Brindley PJ, Kumar R. The metastasis-associated protein-1 gene encodes a host permissive factor for schistosomiasis, a leading global cause of inflammation and cancer. Hepatology. 2011 Jul;54(1):285-95. doi: 10.1002/hep.24354. Epub 2011 Jun 8. PubMed PMID: 21488078; PubMed Central PMCID: PMC3125413.
Vercruysse J, Behnke JM, Albonico M, Ame SM, Angebault C, Bethony JM, Engels  D, Guillard B, Nguyen TV, Kang G, Kattula D, Kotze AC, McCarthy JS, Mekonnen Z, Montresor A, Periago MV, Sumo L, Tchuenté LA, Dang TC, Zeynudin A, Levecke B. Assessment of the anthelmintic efficacy of albendazole in school children in seven countries where soil-transmitted helminths are endemic. PLoS Negl Trop Dis. 2011 Mar 29;5(3):e948. doi: 10.1371/journal.pntd.0000948. PubMed PMID: 21468309;  PubMed Central PMCID: PMC3066140.
Smout MJ, Sripa B, Laha T, Mulvenna J, Gasser RB, Young ND, Bethony JM, Brindley PJ, Loukas A. Infection with the carcinogenic human liver fluke, Opisthorchis viverrini. Mol Biosyst. 2011 May;7(5):1367-75. doi: 10.1039/c0mb00295j. Epub 2011 Feb 11. Review. PubMed PMID: 21311794; PubMed Central PMCID: PMC3739706.
Jex AR, Lim YA, Bethony JM, Hotez PJ, Young ND, Gasser RB. Soil-transmitted helminths of humans in Southeast Asia--towards integrated control. Adv Parasitol. 2011;74:231-65. doi: 10.1016/B978-0-12-385897-9.00004-5. Review. PubMed PMID: 21295679.
Bethony JM, Cole RN, Guo X, Kamhawi S, Lightowlers MW, Loukas A, Petri W, Reed S, Valenzuela JG, Hotez PJ. Vaccines to combat the neglected tropical diseases. Immunol Rev. 2011 Jan;239(1):237-70. doi: 10.1111/j.1600-065X.2010.00976.x. Review. PubMed PMID: 21198676; PubMed Central PMCID: PMC3438653.
2010 Publications
Hotez PJ, Bethony JM, Diemert DJ, Pearson M, Loukas A. Developing vaccines to combat hookworm infection and intestinal schistosomiasis. Nat Rev Microbiol. 2010 Nov;8(11):814-26. Review.
Jariwala AR, Oliveira LM, Diemert DJ, Keegan B, Plieskatt JL, Periago MV, Bottazzi ME, Hotez PJ, Bethony JM. Potency testing for the experimental Na-GST-1 hookworm vaccine. Expert Rev Vaccines. 2010 Oct;9(10):1219-30. Review. 
Gazzinelli MF, Lobato L, Matoso L, Avila R, de Cassia Marques R, Shah Brown A, Correa-Oliveira R, Bethony JM, Diemert DJ. Health education through analogies: preparation of a community for clinical trials of a vaccine against hookworm in an endemic area of Brazil. PLoS Negl Trop Dis. 2010 Jul 20;4(7):e749.
Kouriba B, Traore B, Diemert D, Thera MA, Dolo A, Tounkara A, Doumbo O. Immunity in human schistosomiasis: hope for a vaccine. Med Trop (Mars). 2010 Apr;70(2):189-97. Review. French.
Quinnell RJ, Pullan RL, Breitling LP, Geiger SM, Cundill B, Correa-Oliveira R, Brooker S, Bethony JM. Genetic and household determinants of predisposition to human hookworm infection in a Brazilian community. J Infect Dis. 2010 Sep 15;202(6):954-61. doi: 10.1086/655813. PubMed PMID: 20681887; PubMed Central PMCID: PMC2938471.
Sripa B, Bethony JM, Sithithaworn P, Kaewkes S, Mairiang E, Loukas A, Mulvenna J, Laha T, Hotez PJ, Brindley PJ. Opisthorchiasis and Opisthorchis-associated cholangiocarcinoma in Thailand and Laos. Acta Trop. 2011  Sep;120 Suppl 1:S158-68. doi: 10.1016/j.actatropica.2010.07.006. Epub 2010 Jul 23. Review. PubMed PMID: 20655862; PubMed Central PMCID: PMC3010517.
Pearson MS, Pickering DA, Tribolet L, Cooper L, Mulvenna J, Oliveira LM, Bethony JM, Hotez PJ, Loukas A. Neutralizing antibodies to the hookworm hemoglobinase Na-APR-1: implications for a multivalent vaccine against hookworm infection and schistosomiasis. J Infect Dis. 2010 May 15;201(10):1561-9. doi: 10.1086/651953. PubMed PMID: 20367477.
2009 Publications
Cançado GG, Fujiwara RT, Freitas PA, Correa-Oliveira R, Bethony JM. 
Acute generalized exanthematous pustulosis induced by itraconazole: an immunological approach. Clin Exp Dermatol. 2009 Dec;34(8):e709-11. doi: 10.1111/j.1365-2230.2009.03440.x. Epub 2009 Jul 3. PubMed PMID: 20055840.
Pullan RL, Bethony JM, Geiger SM, Correa-Oliveira R, Brooker S, Quinnell RJ. Human helminth co-infection: no evidence of common genetic control of hookworm and Schistosoma mansoni infection intensity in a Brazilian community. Int J Parasitol. 2010 Mar 1;40(3):299-306. doi: 10.1016/j.ijpara.2009.08.002. Epub 2009 Aug 20. PubMed PMID: 19699204; PubMed Central PMCID: PMC2824627.
Sripa B, Mairiang E, Thinkhamrop B, Laha T, Kaewkes S, Sithithaworn P, Tessana S, Loukas A, Brindley PJ, Bethony JM. Advanced periductal fibrosis from infection with the carcinogenic human liver fluke Opisthorchis viverrini correlates with elevated levels of interleukin-6. Hepatology. 2009 Oct;50(4):1273-81. doi: 10.1002/hep.23134. PubMed PMID: 19676135; PubMed Central  PMCID: PMC3682769
Pearson MS, Bethony JM, Pickering DA, de Oliveira LM, Jariwala A, Santiago H, Miles AP, Zhan B, Jiang D, Ranjit N, Mulvenna J, Tribolet L, Plieskatt J, Smith T, Bottazzi ME, Jones K, Keegan B, Hotez PJ, Loukas A. An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection. FASEB J. 2009 Sep;23(9):3007-19. doi: 10.1096/fj.09-131433. Epub 2009  Apr 20. PubMed PMID: 19380510; PubMed Central PMCID: PMC2735369.
Pearson MS, Bethony JM, Pickering DA, de Oliveira LM, Jariwala A, Santiago H, Miles AP, Zhan B, Jiang D, Ranjit N, Mulvenna J, Tribolet L, Plieskatt J, Smith T, Bottazzi ME, Jones K, Keegan B, Hotez PJ, Loukas A. An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection. FASEB J. 2009 Sep;23(9):3007-19. doi: 10.1096/fj.09-131433. Epub 2009 Apr 20. PubMed PMID: 19380510; PubMed Central PMCID: PMC2735369.
2008 Publications

Miura K, Zhou H, Moretz SE, Diouf A, Thera MA, Dolo A, Doumbo O, Malkin E, Diemert D, Miller LH, Mullen GE, Long CA. Comparison of biological activity of human anti-apical membrane antigen-1 antibodies induced by natural infection and vaccination. J Immunol. 2008 Dec 15;181(12):8776-83. Jardim-Botelho A, Raff S, Rodrigues Rde A, Hoffman HJ, Diemert DJ, Corrêa-Oliveira R, Bethony JM, Gazzinelli MF.

Hookworm, Ascaris lumbricoides infection and polyparasitism associated with poor cognitive performance in Brazilian schoolchildren. Trop Med Int Health. 2008 Aug;13(8):994-1004. Bethony JM, Diemert DJ, Oliveira SC, Loukas A.

Can schistosomiasis really be consigned to history without a vaccine? Vaccine. 2008 Jun 25;26(27-28):3373-6.

Duan J, Mu J, Thera MA, Joy D, Kosakovsky Pond SL, Diemert D, Long C, Zhou H, Miura K, Ouattara A, Dolo A, Doumbo O, Su XZ, Miller L. Population structure of the genes encoding the polymorphic Plasmodium falciparum apical membrane antigen 1: implications for vaccine design. Proc Natl Acad Sci U S A. 2008 Jun3;105(22):7857-62.

Bethony JM, Simon G, Diemert DJ, Parenti D, Desrosiers A, Schuck S, Fujiwara R, Santiago H, Hotez PJ. Randomized, placebo-controlled, double-blind trial of the Na-ASP-2 hookworm vaccine in unexposed adults. Vaccine. 2008 May2;26(19):2408-17.

Jardim-Botelho A, Brooker S, Geiger SM, Fleming F, Souza Lopes AC, Diemert DJ, Corrêa-Oliveira R, Bethony JM. Age patterns in undernutrition and helminth infection in a rural area of Brazil: associations with ascariasis and hookworm. Trop Med Int Health. 2008 Apr;13(4):458-67. Diemert DJ, Bethony JM, Hotez PJ.

Hookworm vaccines. Clin Infect Dis. 2008 Jan 15;46(2):282-8. Review.

Pullan RL, Bethony JM, Geiger SM, Cundill B, Correa-Oliveira R, Quinnell RJ,  Brooker S. Human helminth co-infection: analysis of spatial patterns and risk factors in a Brazilian community. PLoS Negl Trop Dis. 2008;2(12):e352. doi: 10.1371/journal.pntd.0000352. Epub 2008 Dec 23. PubMed PMID: 19104658; PubMed Central PMCID: PMC2602736.

Geiger SM, Fujiwara RT, Santiago H, Corrêa-Oliveira R, Bethony JM. Early stage-specific immune responses in primary experimental human hookworm infection. 
Microbes Infect. 2008 Nov-Dec;10(14-15):1524-35. doi: 10.1016/j.micinf.2008.09.003. Epub 2008 Sep 23. PubMed PMID: 18848637.

Teixeira-Carvalho A, Fujiwara RT, Stemmy EJ, Olive D, Damsker JM, Loukas A, Corrêa-Oliveira R, Constant SL, Bethony JM. Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil. Infect Immun. 2008 Dec;76(12):5810-6. doi: 10.1128/IAI.00419-08. Epub 2008 Oct 6. PubMed PMID: 18838519; PubMed Central PMCID: PMC2583555.

Don TA, Bethony JM, Loukas A. Saposin-like proteins are expressed in the gastrodermis of Schistosoma mansoni and are immunogenic in natural infections. Int J Infect Dis. 2008 Nov;12(6):e39-47. doi: 10.1016/j.ijid.2007.10.007. Epub 2008 Jun 20. PubMed PMID: 18571965.

Loukas A, Bethony JM. New drugs for an ancient parasite. Nat Med. 2008 Apr;14(4):365-7. doi: 10.1038/nm0408-365. PubMed PMID: 18391931.

Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, Jacobson J. Helminth infections: the great neglected tropical diseases. J Clin Invest. 2008 Apr;118(4):1311-21. doi: 10.1172/JCI34261. Review. PubMed PMID: 18382743; PubMed  Central PMCID: PMC2276811.

Bethony JM, Loukas A. The schistosomiasis research agenda--what now? PLoS Negl Trop Dis. 2008 Feb 27;2(2):e207. doi: 10.1371/journal.pntd.0000207. PubMed PMID: 18301729; PubMed Central PMCID: PMC2254202.

Hotez PJ, Bethony JM, Oliveira SC, Brindley PJ, Loukas A. Multivalent anthelminthic vaccine to prevent hookworm and schistosomiasis. Expert Rev Vaccines. 2008 Aug;7(6):745-52. doi: 10.1586/14760584.7.6.745. Review. PubMed PMID: 18665774.
2007 Publications
Dicko A, Sagara I, Diemert D, Sogoba M, Niambele MB, Dao A, Dolo G, Yalcouye D, Diallo DA, Saul A, Miller LH, Toure YT, Klion AD, Doumbo OK. Year-to-year variation in the age-specific incidence of clinical malaria in two potential vaccine testing sites in Mali with different levels of malaria transmission intensity.
Am J Trop Med Hyg. 2007 Dec;77(6):1028-33
Dicko A, Diemert DJ, Sagara I, Sogoba M, Niambele MB, Assadou MH, Guindo O, Kamate B, Baby M, Sissoko M, Malkin EM, Fay MP, Thera MA, Miura K, Dolo A, Diallo DA, Mullen GE, Long CA, Saul A, Doumbo O, Miller LH. Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians. PLoS One. 2007 Oct 17;2(10):e1045.
Geiger SM, Caldas IR, Mc Glone BE, Campi-Azevedo AC, De Oliveira LM, Brooker S, Diemert D, Corrêa-Oliveira R, Bethony JM. Stage-specific immune responses in human Necator americanus infection. Parasite Immunol. 2007 Jul;29(7):347-58.
Diemert DJ, Bethony JM. Re: Clinical trials in tropical diseases: a politically incorrect view. Trop Med Int Health. 2007 Mar;12(3):470-1.
Bethony JM, Quinnell RJ. Genetic epidemiology of human schistosomiasis in Brazil. Acta Trop. 2008 Nov-Dec;108(2-3):166-74. doi:  10.1016/j.actatropica.2007.11.008. Epub 2007 Dec 8. Review. PubMed PMID:
18207118.
Sripa B, Kaewkes S, Sithithaworn P, Mairiang E, Laha T, Smout M, Pairojkul C, Bhudhisawasdi V, Tesana S, Thinkamrop B, Bethony JM, Loukas A, Brindley PJ. Liver fluke induces cholangiocarcinoma. PLoS Med. 2007 Jul;4(7):e201. Review. PubMed PMID: 17622191; PubMed Central PMCID: PMC1913093.
Fujiwara RT, Zhan B, Mendez S, Loukas A, Bueno LL, Wang Y, Plieskatt J, Oksov Y, Lustigman S, Bottazzi ME, Hotez P, Bethony JM. Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16. Clin Vaccine Immunol. 2007 Mar;14(3):281-7. Epub 2007 Jan 31. PubMed PMID: 17267592; PubMed Central PMCID: PMC1828853.
Fujiwara RT, Zhan B, Mendez S, Loukas A, Bueno LL, Wang Y, Plieskatt J, Oksov Y, Lustigman S, Bottazzi ME, Hotez P, Bethony JM. Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16. Clin Vaccine Immunol. 2007 Mar;14(3):281-7. Epub 2007 Jan 31. PubMed PMID: 17267592; PubMed Central PMCID: PMC1828853.
2006 Publications
Thera MA, Doumbo OK, Coulibaly D, Diallo DA, Sagara I, Dicko A, Diemert DJ, Heppner DG Jr, Stewart VA, Angov E, Soisson L, Leach A, Tucker K, Lyke KE, Plowe CV; Mali FMP1 Working Group. Safety and allele-specific immunogenicity of a malaria vaccine in Malian adults: results of a phase I randomized trial. PLoS Clin Trials. 2006 Nov 24;1(7):e34.
Diemert DJ. Prevention and self-treatment of traveler's diarrhea. Clin Microbiol Rev. 2006 Jul;19(3):583-94. Review.
Hotez PJ, Bethony J, Bottazzi ME, Brooker S, Diemert D, Loukas A. New technologies for the control of human hookworm infection. Trends Parasitol. 2006 Jul;22(7):327-31.Review.
Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, Diemert D, Hotez PJ. Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet. 2006 May 6;367(9521):1521-32. Review.
Bottazzi ME, Miles AP, Diemert D, Hotez PJ. An ounce of prevention on a budget: a nonprofit approach to developing vaccines against neglected diseases. Expert Rev Vaccines. 2006 Apr;5(2):189-98. Review.
Bethony JM, Loukas A, Hotez PJ, Knox DP. Vaccines against blood-feeding nematodes of humans and livestock. Parasitology. 2006;133 Suppl:S63-79. Review. PubMed PMID: 17274849.
Brooker S, Jardim-Botelho A, Quinnell RJ, Geiger SM, Caldas IR, Fleming F, Hotez PJ, Correa-Oliveira R, Rodrigues LC, Bethony JM. Age-related changes in hookworm infection, anaemia and iron deficiency in an area of high Necator americanus hookworm transmission in south-eastern Brazil. Trans R Soc Trop Med Hyg. 2007 Feb;101(2):146-54. Epub 2006 Oct 5. PubMed PMID: 17027054.
Mwangi TW, Bethony JM, Brooker S. Malaria and helminth interactions in humans: an epidemiological viewpoint. Ann Trop Med Parasitol. 2006 Oct;100(7):551-70. Review. PubMed PMID: 16989681; PubMed Central PMCID: PMC1858631.
Tran MH, Pearson MS, Bethony JM, Smyth DJ, Jones MK, Duke M, Don TA, McManus  DP, Correa-Oliveira R, Loukas A. Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis. Nat Med. 2006 Jul;12(7):835-40. Epub 2006 Jun 18. PubMed PMID: 16783371.
Fleming FM, Brooker S, Geiger SM, Caldas IR, Correa-Oliveira R, Hotez PJ, Bethony JM. Synergistic associations between hookworm and other helminth species in a rural community in Brazil. Trop Med Int Health. 2006 Jan;11(1):56-64. PubMed PMID: 16398756.
2005 Publications
Malkin EM, Diemert DJ, McArthur JH, Perreault JR, Miles AP, Giersing BK, Mullen GE, Orcutt A, Muratova O, Awkal M, Zhou H, Wang J, Stowers A, Long CA, Mahanty S, Miller LH, Saul A, Durbin AP. Phase 1 clinical trial of apical membrane antigen 1: an asexual blood-stage vaccine for Plasmodium falciparum malaria. Infect Immun. 2005 Jun;73(6):3677-85.
Malkin EM, Durbin AP, Diemert DJ, Sattabongkot J, Wu Y, Miura K, Long CA, Lambert L, Miles AP, Wang J, Stowers A, Miller LH, Saul A. Phase 1 vaccine trial of Pvs25H: a transmission blocking vaccine for Plasmodium vivax malaria. Vaccine. 2005 May 2;23(24):3131-8. 
Ndao M, Bandyayera E, Kokoskin E, Diemert D, Gyorkos TW, MacLean JD, St John R, Ward BJ. Malaria "epidemic" in Quebec: diagnosis and response to imported malaria. CMAJ. 2005 Jan 4;172(1):46-50.
Loukas A, Bethony JM, Mendez S, Fujiwara RT, Goud GN, Ranjit N, Zhan B, Jones K, Bottazzi ME, Hotez PJ. Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogs. PLoS Med.  2005 Oct;2(10):e295. Epub 2005 Oct 4. PubMed PMID: 16231975; PubMed Central PMCID: PMC1240050.
Zhan B, Liu S, Perally S, Xue J, Fujiwara R, Brophy P, Xiao S, Liu Y, Feng J, Williamson A, Wang Y, Bueno LL, Mendez S, Goud G, Bethony JM, Hawdon JM, Loukas A, Jones K, Hotez PJ. Biochemical characterization and vaccine potential of a heme-binding glutathione transferase from the adult hookworm Ancylostoma caninum. Infect Immun. 2005 Oct;73(10):6903-11. PubMed PMID: 16177370; PubMed Central PMCID: PMC1230892
Fujiwara RT, Loukas A, Mendez S, Williamson AL, Bueno LL, Wang Y, Samuel A, Zhan B, Bottazzi ME, Hotez PJ, Bethony JM. Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs. Vaccine. 2006 Jan 23;24(4):501-9. Epub 2005 Aug 15. PubMed PMID: 16140437.
Fujiwara RT, Vale AM, França da Silva JC, da Costa RT, Quetz Jda S, Martins Filho OA, Reis AB, Corrêa Oliveira R, Machado-Coelho GL, Bueno LL, Bethony JM, Frank G, Nascimento E, Genaro O, Mayrink W, Reed S, Campos-Neto A. Immunogenicity in dogs of three recombinant antigens (TSA, LeIF and LmSTI1) potential vaccine candidates for canine visceral leishmaniasis. Vet Res. 2005 Sep-Dec;36(5-6):827-38. PubMed PMID: 16120256.
Loukas A, Constant SL, Bethony JM. Immunobiology of hookworm infection. FEMS Immunol Med Microbiol. 2005 Feb 1;43(2):115-24. Review. PubMed PMID: 15681140.
Goud GN, Bottazzi ME, Zhan B, Mendez S, Deumic V, Plieskatt J, Liu S, Wang Y, Bueno L, Fujiwara R, Samuel A, Ahn SY, Solanki M, Asojo OA, Wang J, Bethony JM, Loukas A, Roy M, Hotez PJ. Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials. Vaccine. 2005 Sep 15;23(39):4754-64. PubMed PMID: 16054275.
2001 Publications
Hotez PJ, Brooker S, Bethony JM, Bottazzi ME, Loukas A, Xiao S. Hookworm infection. N Engl J Med. 2004 Aug 19;351(8):799-807. Review. PubMed PMID:15317893.
Loukas A, Bethony JM, Williamson AL, Goud GN, Mendez S, Zhan B, Hawdon JM, Elena Bottazzi M, Brindley PJ, Hotez PJ. Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of worms. J Infect Dis. 2004 May 15;189(10):1952-61. Epub 2004 Apr 27. PubMed PMID: 15122534.
Hotez PJ, Zhan B, Bethony JM, Loukas A, Williamson A, Goud GN, Hawdon JM, Dobardzic A, Dobardzic R, Ghosh K, Bottazzi ME, Mendez S, Zook B, Wang Y, Liu S,  Essiet-Gibson I, Chung-Debose S, Xiao S, Knox D, Meagher M, Inan M, Correa-Oliveira R, Vilk P, Shepherd HR, Brandt W, Russell PK. Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative. Int J Parasitol. 2003 Sep 30;33(11):1245-58. Review. PubMed PMID: 13678639.
Bethony J, Loukas A, Smout M, Brooker S, Mendez S, Plieskatt J, Goud G, Bottazzi ME, Zhan B, Wang Y, Williamson A, Lustigman S, Correa-Oliveira R, Xiao S, Hotez PJ. Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals. FASEB J. 2005 Oct;19(12):1743-5. Epub 2005 Jul 21. PubMed PMID: 16037096.